The following text is written by Dr. Neil Solomon:
"Before delving into each of the specific health conditions for which people use noni, I want to quickly summarize how I believe noni is able to help so many different health problems. While the working theory I am about to present does not cover the only reason noni is such an effective natural health supplement, I believe it does help explain why this ancient fruit is able to improve the symptoms of so many varied types of health problems.
One of these theories used to explain noni's health effects revolves around one of its putative main components -proxeronine. It is believed that once in the body, proxeronine travels to specific parts of the cells, such as the mitochondria, microsomes, Golgi apparatus, reticuloendothelium, electron transport system, DNA, RNA, etc. Within the cell, these components communicate with each other (intracellular) and with other cells (intercellular). It is established by Dr. Anne Hirazumi that noni augments the release of high amounts of nitric oxide from immune cells. I coupled her work with the work from the 1998 Nobel Prize winners in medicine who are Drs. Robert Fuchgott, Feried Murad, and Louis Igano. These scientists demonstrated that nitric oxide in low concentrations allows cells to communicate with each other. Nitric oxide becomes one of their special languages. The 1999 Nobel Prize was awarded to Rockerfeller University Biologist Dr. Guenther Blobel who explained how proteins are shipped to cells using a "postal and zip code" sort of system. I believe when a person does not have optimal health, it is because some cells are sick.
Relying on research from other scientists, I have constructed my own theory about how the body is able to distribute the important biochemical compounds in noni. According to the theory, once in the body proxeronine travels to specific cells and settles in the cell's Golgi apparatus and reticuloendothelium. Within these structures, proxeronine combines with other natural biochemicals and building blocks (i.e. hormones, proteins, enzymes, serotonin, vitamins, minerals, and antioxidants) where it exerts its action. It is postulated the Golgi apparatus and the reticuloendothelium then assemble all the necessary compounds into a specific "package" and deliver the "package" to the parts of the cell which are sick, or they may carry the "package" via the blood stream to other sick cells in other parts of the body, similar to how letters are sent to a specific address based upon the specified postal code. This is called the Noni Phenomenon.
As the receiving cell opens the "package" sent by the Golgi apparatus and the reticuloendothelium, the packaged proxeronine combines with another cellular enzyme called proxeroninease. According to the research by Dr. Ralph Heinicke, this combination converts into xeronine. Others believe that xeronine aids the cell to repair and regenerate itself. This is one way I believe that noni juice helps the body heal itself.
A simple illustration of this would be to compare proxeronine to that of a conductor of a symphony orchestra. Just as a conductor skillfully conducts the participants in an orchestra, proxeronine directs the various amounts of nutraceuticals, other natural biochemicals and building blocks (i.e. hormones, proteins, enzymes, serotonin, vitamins, antioxidants) to go to that part of the sick cell(s) to help in healthy regeneration. Once this happens, under the direction of its conductor the cells once again work in harmony and play beautiful, helpful music.
One might logically ask why use noni juice to replenish proxeronine? Why not obtain it from food? The answer is simple. Noni IS a food and is by far the richest known source of proxeronine. It has more than forty times more proxeronine than its closest competitor, pineapple."
*Adapted from the book: "TAHITIAN NONI Juice: How Much, How Often, For What" by Dr. Neil Solomon, MD,